Nasal spray for Covid-19
Recently, scientists have discovered a new compound supplied in nasal sprays (image) is highly effective in preventing as well as Covid-19 disease treatment caused by the Delta variant.
The specially designed compound, called N-0385, blocks the action of an enzyme in humans infected with the virus SARS-CoV-2 used to infect host cells. This compound was developed by scientists at the University of Sherbrooke (Canada).
Researchers at the University of British Columbia (Canada) then cultured lung cells in the laboratory and infected them with four variants of SARS-CoV-2, including Delta. The results showed that, N-0385 could inhibit the infection and there was no evidence of toxicity.
In a recent publication, researchers at Cornell University (USA) injected a certain amount of N-0385 into genetically engineered mice infected with SARS-CoV-2. N-0385 was infused into rats with a nasal spray for 4 days. All 10 treated mice survived Covid-19 infection, compared with untreated mice who only survived 20%.
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“This compound is unique because it blocks entry at the cell surface without having to enter the cell. This prevents the virus from causing detectable cell damage. In addition, N-0385 is very potent, requiring only small amounts to be effective,” said Dr Andrea Olmstead, department of microbiology and immunology at the University of British Columbia, study co-author, on the page. SciTechDaily.
The team also expects N-0385 to be able to suppress the variant Omicron cause infection in human lung cells. The scientists say the compound also has the potential to be used as a broad-spectrum treatment against other viruses that use a similar mechanism to influenza A, influenza C and H1N1.
If approved, N-0385 would be optimized for use in combination with recently approved drugs in the treatment of Covid-19according to SciTechDaily.
at Blogtuan.info – Source: thanhnien.vn – Read the original article here
