My first child has hemophilia, what should I do to give birth to a healthy baby?
Ask: I am 35 years old this year, married in 2010, I gave birth in 2011 to an unfortunate boy with hemophilia (I myself carry the disease gene). Since then, every month, the baby has to take medicine and be monitored at the hospital. I plan to have more children this year, is there any way to have a healthy baby without getting sick like my son?
Doctor Dao Van Kien (Specialized in Reproductive Support, Hanoi Hospital of Andrology and Infertility) replied as follows:
Doctor Dao Van Kien – Specializing in Reproductive Support, Hanoi Hospital of Andrology and Infertility.
Hello!
Hemophilia is a disease blood clotting disorder due to a lack of one of the three clotting factors (factors VIII, IX and X), the disease is uncommon, mainly in 3 – 5 boys/100,000 births.
Hemophilia A (factor VIII deficiency), which accounts for about 80% of patients with hemophilia, and hemophilia B (factor IX deficiency) have similar clinical presentation and initial screening tests. Both are X-linked recessive genetic disorders. Quantification of specific factors will confirm the diagnosis of hemophilia.
Hemophilia is an inherited disorder caused by deletions, inversions, or deletions affecting the factor VIII or factor IX gene.
Because these genes are located on the X chromosome, hemophilia occurs mainly in males. The daughters of a man with hemophilia are carriers of the disease but have normal sons. The son of a mother carrying the disease gene has a 50% chance of having the disease, and a daughter has a 50% chance of carrying the disease gene.
It is now possible to exclude cases of disease or carriers of hemophilia by the method of In Vitro Fertilisation and preimplantation genetic testing. In vitro fertilization is a method of assisted reproduction for infertile couples by combining eggs and sperm outside the body. The embryo that is formed after fertilization is transferred back to the woman’s uterus. The embryo then implants and develops into a fetus as in cases of natural conception.
Preimplantation Genetic Testing (PGT) is a set of specialized techniques used to identify genetic abnormalities of embryos produced by in vitro fertilization.
Through these tests, experts can select healthy embryos to transfer into the uterus, increasing the chances of success and helping couples have healthy babies, free of the hemophilia gene. Preimplantation genetic testing involves 3 main groups of tests:
• PGT-M: Testing for single-gene genetic diseases.
• PGT-SR: Testing for structural abnormalities of chromosomes.
• PGT-A: Tests for chromosome number abnormalities.
In the case of the family, doctors will support you to get pregnant by in vitro fertilization, creating embryos. Then, by preimplantation genetic testing, PGT-M will select good quality embryos that do not carry the hemophilia gene and transfer them to the wife’s uterus to give birth to healthy babies.
Hope you and your family welcome a new member soon!
at Blogtuan.info – Source: Afamily.vn – Read the original article here
