Latest Nano technology in medicine
Acute respiratory distress syndrome (ARDS) with manifestations such as shortness of breath, cyanosis of the lips, and extremities is one of the most common complications of COVID-19. If ARDS has inflammation that progresses rapidly and spreads to the entire lung, it increases the risk of death for the patient.
Some patients, despite being cured, still face post-COVID-19 sequelae such as damage to the lung parenchyma, leading to persistent pulmonary fibrosis and persistent systemic complications.
Nano Ceria prevents cytokine storm – the main cause of acute respiratory distress syndrome
Cytokine storm occurs when an agent enters the body, the immune system is activated to help fight the agent, the pathogen. Cytokines send signals to immune cells and in turn trigger the massive release of cytokines.
These cytokines attack the lungs and disrupt lung tissue. When the lungs are severely damaged and cause acute respiratory distress syndrome. Without prompt treatment, cytokine storms in COVID-19 patients pose significant health risks and can lead to death. To prevent this, there is a need for pharmacotherapy that reduces the progression of cytokine storms, reduces overall inflammation, and provides a beneficial response to the patient.
Nano Ceria has been shown to modulate the cytokine production pathways of the NF-ĸB protein complex during the immune response to inflammation. From there, Nano Ceria directly reduces cytokine synthesis, or blocks the action by disrupting the interaction between cytokine receptors. As a result, Nano Ceria intervention can significantly reverse elevated cytokine levels during SARS-CoV-2 infection, helping to prevent disease progression and respiratory failure.
Nano Ceria has the ability to prevent pulmonary fibrosis and other lung damage
In ARDS, rapidly progressive inflammation of the entire lung increases the risk of death. The image of pulmonary fibrosis of a patient with ARDS after COVID-19 has features such as: white membrane like fluid accumulation in the lungs, lung-like image after drowning.
Furthermore, pulmonary fibrosis is one of the complicated complications and needs to be monitored in COVID-19 patients with underlying respiratory diseases such as emphysema. Without respiratory support, the patient may lose the ability to breathe because of pulmonary fibrosis.
In order to prevent pulmonary fibrosis, it is necessary to inhibit with medicinal herbs TGF-β (a protein that acts as epidermal growth factor) signals, thereby limiting scarring and fibrotic lesions in the inflamed area. In preclinical studies, Nano Ceria was shown to effectively reduce liver fibrosis and collagen deposition by inhibiting multiple TGF-β. Patients using Nano Ceria as an adjuvant during treatment will limit pulmonary fibrosis and protect healthy lungs during the COVID-19 pandemic.
Mechanism of lung damage when patients are infected with SARS-CoV-2
How can systemic complications of COVID-19 be managed?
After being infected with SARS-CoV-2, depending on the severity, the patient will experience typical systemic complications such as acute pneumonia, liver, heart, and kidney damage, secondary infection, hair loss. problems with smell, taste, memory, trouble sleeping, difficulty concentrating, multisystem inflammatory syndrome in children, disseminated intravascular coagulation, etc.
Systemic complications associated with COVID-19 stem from redox imbalance, a disordered oxidant and antioxidant homeostasis, resulting in cellular damage. Reactive oxygen species (ROS) interfere with redox processes, resulting in impaired redox control, and cell signaling becomes unstable. These make the disease worse.
Nano Ceria acts as a filter with reactive oxygen species, does not damage cells, reduces damage in various diseases. This active ingredient reduces the redox breakdown of lipids, improves levels of immune support and slows the aging process, as well as stimulates the activity of important enzymes in the immune system that fight oxygen. chemical. These effects make Nano Ceria a potential candidate for the management of systemic complications of COVID-19.
4 preeminent effects of Nano Ceria active ingredient on COVID-19 patients
Despite possessing many ideal medicinal properties for the treatment of COVID-19, Nano Ceria has not yet been widely used in the preparation of health care products and medical treatment. But this is also a good signal that the future of human control of the COVID-19 pandemic is not too far away.
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at Blogtuan.info – Source: cafebiz.vn – Read the original article here
