Infertility still has children, miracles come to those who think they are forever “lost breed”

Ever thought of a divorce?

In the early days of May, when the sun was shining like fire, Mr. Linh (Thieu Hoa, Thanh Hoa) was busy making milk tea to sell to customers. From time to time he looked out at his 1-year-old daughter who was learning to walk with affectionate eyes.

Taking advantage of the absence of guests, he said that sometimes he still can’t believe “I can be a father again”. 6 years ago, Ms. Nguyen Thi Huong (born in 1992) “fallen in love” at first sight when Mr. Nguyen Manh Linh of the same age came to the “saw” house.

Linh and Huong are happy with their daughter

“He’s tall and handsome, so we got married after being in love. As an only child, the parents wanted to have a grandchild, so the couple also released it naturally but… 6 months had no results. Impatient, the couple took each other to see a doctor. And the sad news came when the doctor said that my husband was infertile, so the chance of becoming a father was almost zero”, Huong Ngan recalls with tears in her eyes.

Surprised by that result but did not give up, the couple took each other to visit many places, who told what medicine, which teacher, where, they all tried to find treatment for 5 years, but it did not bring results. result.

There were times when he thought he was powerless, the family atmosphere was heavy, the man used to silently learn about his illness but almost fell into… stalemate. “I used to think that I would ‘liberate her’,” Linh said.

To tell this to his wife, he had to struggle terribly. Husband and wife living together for a day should also be meaningful. “But honestly the pressure is terrible. Especially when neighbors and acquaintances keep asking about their children. At such times, the face can only be bowed, “said Linh.

Knowing that her husband is self-deprecating and depressed, Huong is still with him. She is strong, shares, encourages her husband to hope, looks for opportunities.

“Actually, in the beginning, we also knew there was an opportunity, but the cost like everyone said it would take hundreds of millions. The newlyweds didn’t get that much, so they had to return in the hope of finding their children in another way. But the longer I wait, the less I see it. When I decided to sell my house, I accepted it, God loved it, and brought the baby to us”, Mr. Linh burst with joy.

That was when through acquaintances, he sought out doctors at Hanoi Hospital for Menopause and Infertility. After examination, tests, and scans, Linh officially knew that the cause of his infertility was because he had a rare Klinefelter syndrome.

Currently, the only method that offers a chance of having a baby for patients with Klinefelter syndrome is micro-testicular surgery to find sperm – Micro TESE and use that sperm to fertilize in vitro with the wife’s egg.

Sweet fruit

MSc. Dr. Dinh Huu Viet, Head of the Department of Andrology (Hanoi Hospital of Andrology and Infertility), who directly examines and treats Mr and Mrs. Linh, said that male infertility due to Klinefelter syndrome accounts for about 3 % and are often classified as “difficult cases” in assisted reproductive and gynecological interventions.

Klinefelter syndrome is an inherited disorder in men. Men with this syndrome have a pair of X sex chromosomes instead of just one X chromosome, have chromosome set (chromosome) 47XXY (normally 46XY) characterized by hypogonadism, disorder endocrine system, testicular atrophy, poor spermatogenesis or no spermatogenesis.

MSc Dinh Huu Viet (white mask) performed testicular microsurgery to find sperm – Micro TESE for azoospermia patients

“Therefore, without the intervention of assisted reproductive methods, the patient will not be able to have a natural child,” informed Dr. Dinh Huu Viet.

However, by using Micro TESE method, Hanoi Hospital of Andrology and Infertility has helped many cases of this syndrome have their own children. In fact, cases of infertility due to nonobstructive azoospermia represent a major challenge in the treatment of male infertility.

At this time, Micro TESE is almost the only method to find sperm and use that sperm to do in vitro fertilization with the wife’s eggs. “It is conceivable that this is a deep intervention method for the doctor to remove each layer of testicular tissue to “catch” each sperm. And Mr. Linh and Mrs. Huong are one of such couples.

“I still clearly remember the process of performing surgery on the patient, the joy was bursting when I found 1,2,3 then 5,6, …9,10 sperm, enough to perform fertilization with the number of eggs. of the wife,” said Dr. Dinh Huu Viet.

Through this case, Mr. Dr. Dinh Huu Viet noted that Klinefelter patients are usually not affected much in the process of living and growing up, so they are almost always detected late. Men only go to the doctor until they get married and have children later to find out that there is no sperm in the semen.

At this time, only specialized tests can detect chromosomal abnormalities. That is also the general situation of patients when they come to the hospital for examination. The late diagnosis of the disease, when the patient is old, also greatly affects the later treatment process.

Therefore, general advice for couples who have had regular sex, have not used contraception for 1 year or 6 months (for women over 35 years old) and still do not have children should see a doctor. reproductive health check.

In addition to being widely applied to male infertility due to Klinefelter syndrome, Micro TESE is also commonly indicated for most cases of nonobstructive infertility due to causes such as: testicular atrophy. Mumps due to mumps, Sertoli syndrome, mid-spermoid syndrome, genetic abnormalities (most commonly AZF gene deletion mutation on Y chromosome), chromosomal abnormalities, … There are many diseases azoospermia have done PESA, TESE techniques did not find sperm was successful thanks to Micro TESE.

N. Huyen